Manlius is a town in Onondaga County, east of the city of Syracuse, New York, in the United States. The population was 32,370 at the 2010 census, making it the third largest suburb in metropolitan Syracuse. In 2005, the town was ranked #98 on CNN Money's list of Best Places to Live.The Town of Manlius includes a village also named Manlius, along with the villages of Fayetteville and Minoa. It is located on the eastern border of Onondaga County.